Issue:
A major pharmaceutical client sought to leverage data from a single arm, US-based study on oncology to compare with results published ex-US where the ex-US patient-level data was not available
Solution:
- DMS extracted from the published ex-US data the key descriptive statistics information that was available. Synthetic data sets replicating this information were developed and then a series of matching algorithms and parameters were developed to identify the best match between the US-based data and the published ex-US data.
- Our analyses demonstrated that after matching for the patient characteristics, the US data was similar in terms of outcomes to the ex-US. Moreover, this research was identified by the pharmaceutical client as one of the top innovative projects within their company.
